BioJava is an open source Java library for bioinformatics. It is highly object oriented, allowing extensive customization without extensive code writing. The project is coordinated from the web site at http://www.biojava.org and the mailing list for related discussion is biojava-1@biojava.org.
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Pocock et al. (2000) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: