The immobilization of glucose isomerase in several types of asymmetric hollow fibers is described and evaluated experimentally. The time course of glucose production from 1M fructose at 60°C was similar for the free enzyme and for a hollow fiber enzyme reactor operated under total recycle. Stability of glucose isomerase in a hollow fiber reactor approached that of the free enzyme, although polysulfone fibers had to be preconditioned with an inert protein.
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Korus et al. (1977) studied this question.
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