Key result
Hernia of Morgagni was significantly associated with trisomy 21 (P < 10^-6), with 3 out of 5 recorded liveborn infants with the hernia also having the condition.
There is a significant association between the hernia of Morgagni and trisomy 21, which may reflect defective dorsoventral migration of rhabdomyoblasts.
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Does not warrant practice change; hypothesis-generating for trisomy 21 link in Morgagni hernia.
Of the 5 liveborn infants with the hernia of Morgagni recorded in the California Birth Defects Monitoring Program, 3 had trisomy 21. This significant association (P < 10(-6)) between the hernia of Morgagni and trisomy 21 may reflect defective dorsoventral migration of rhabdomyoblasts from the paraxial myotomes, caused by increased cellular adhesiveness in trisomy 21.
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Honoré et al. (1993) studied this question. Hernia of Morgagni was significantly associated with trisomy 21 (P < 10^-6), with 3 out of 5 recorded liveborn infants with the hernia also having the condition.
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