Griseofulvin in Acute Gout

GRISEOFULVIN is an antifungal antibiotic agent originally isolated from Penicillium griseofulvum by Oxford et al.1 in 1939. It has proved of value in the treatment of superficial mycoses. The drug is incorporated into the keratin of the skin, hair and nails,2 and this factor, combined with its intrinsic antibiotic action, makes it particularly effective in the therapy of various cutaneous fungous infections.Paget and Walpole3 noted that parenteral administration to laboratory animals caused arrested mitosis in metaphase, an effect similar to that of colchicine.Slonim, Howell and Brown,4 in a brief report, stated that griseofulvin (Fig. 1) had a chemical . . .