All articles of this category An efficient and stereodefined process is described for the preparation of 2,3,4-trisubstituted tetrahydrofuran lignans, sesaminone and 4-epidihydrosesamin. The synthetic strategy is based on the similar chemoselective hydrogenation of functionalized lactol derivatives, elaborated through asymmetric condensation of a 4,5- trans -disubstituted lactone. sesaminone - dihydrosesamin - lignan - chemoselective deoxygenation - trisubstituted γ -lactone
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Yoda et al. (2001) studied this question.