Key result
A computational model of ryanodine receptor adaptation demonstrates that adaptation is not essential for the existence of Ca2+ oscillations, though it influences their shape and period.
A kinetic model of RyR adaptation demonstrates that Ca2+ oscillations in cardiac cells depend primarily on store refilling rates rather than solely on RyR adaptation.
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Challenges necessity of ryanodine receptor adaptation for Ca2+ oscillations in models; leaves open its in vivo role in human arrhythmia mechanisms.
Keizer et al. (1996) studied Ca2+ oscillations in cardiac cells. Computational model of ryanodine receptor adaptation was evaluated on Ca2+ oscillations and steady states. A computational model of ryanodine receptor adaptation demonstrates that adaptation is not essential for the existence of Ca2+ oscillations, though it influences their shape and period.
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