The recent announcement that WHO has approved the use of a combination of nifurtimox and eflornithine to treat chronic Gambian sleeping sickness, caused by Trypanosoma brucei gambiense, is a welcome step in the seemingly interminable process of searching for less toxic drugs to treat this devastating disease [1]. Arsenical drugs were first used in 1905; melarsoprol remains the drug most frequently used for late stage disease and is a drug for which resistance is now a major problem [2].
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Molyneux et al. (2010) studied this question.