Acute Experimental Pancreatitis

An antitryptic agent (Trasylol), a polyvalent proteolytic enzyme inhibitor, was used to treat four types of experimental pancreatitis. Acute hemorrhagic pancreatitis was induced in 48 dogs by injection of dilute staphylococcic toxin into the major pancreatic duct and in 15 dogs by creation of a blind duodenal loop. Mortality and severity of pancreatitis were similar for 27 untreated dogs and 36 treated dogs. Acute interstitial pancreatitis was induced in 100 rats by obstruction of the common biliary-pancreatic outflow channel. Significant reduction in mortality of treated rats was noted only when bile was excluded from the obstructed pancreas. Treatment with Trasylol may reduce mortality when the pancreatic duct is obstructed and bile is excluded from the pancreas. In these experiments Trasylol had no significant effect on the course of acute hemorrhagic pancreatitis.