Key result
Trypanosoma cruzi modulates host cell apoptotic pathways, which plays a crucial role in the progression of chronic chagasic cardiomyopathy.
Why the study?
Trypanosoma cruzi modulates host apoptotic pathways, which may influence cardiac alterations and help clarify events preceding chagasic cardiomyopathy.
Modulation of host cell apoptosis by Trypanosoma cruzi plays a fundamental role in the pathogenesis and progression of chronic chagasic cardiomyopathy.
Supports apoptosis modulation as a research target in chagasic cardiomyopathy; leaves open therapeutic translation pending prospective studies.
Chagas disease, a parasitic infection caused by the intracellular protozoan Trypanosoma cruzi, affects millions of people worldwide, and South American countries are among the most affected. This disease has a clinical course that varies from the acute asymptomatic phase to the chronic phase with the presence of important alterations that compromise the cardiac and digestive systems. Studies have shown that the life cycle of the parasite impacts on the modulation of apoptosis, revealing a complex pathogen-host interaction that can substantially influence the development of cardiac alterations. This intriguing strategy used by Trypanosoma cruzi has been increasingly explored and thus it is expected to be able to better clarify the events that precede the development of chagasic cardiomyopathy.
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Pidone et al. (2020) conducted a review in Chagas disease. Trypanosoma cruzi infection was evaluated. Trypanosoma cruzi modulates host cell apoptotic pathways, which plays a crucial role in the progression of chronic chagasic cardiomyopathy.
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