A flexible synthesis of D,L-γ-hydroxyphosphinothricin (GHPPT), a potent inhibitor of the enzyme glutamine synthetase, is described which features silicon-mediated addition of ethyl methylphosphinate to benzyl 2-benzyloxy-carbonylamino-4-oxobutyrate; selective deprotections yield the title compound and various derivatives.
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Walker et al. (1987) studied this question.