Potentiometric creatinine microsensors were fabricated by use of a composite film consisting of polyion complex (PIC), which contains creatinine iminohydrolase (CIH), and the electrochemically inactive polypyrrole (iPPy). The PPy/PIC‐CIH composite film electrode displayed potential response to creatinine concentration owing to a pH change occurring during the enzymatic reaction. The sensitivity was varied by using different polyions of the PIC. With poly‐L‐lysine and sebacic acid, the iPPy/PIC‐CIH electrode demonstrated a high sensitivity (29.8 mV decade −1 ) and a low detection limit ( 1 × 10 − 6 mol dm − 3 ) , which allow one to monitor creatinine concentration in the physiological range.
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Ōsaka et al. (1998) studied this question.