Memory sites toward clinically relevant creatinine have been imparted in polymers based on methacrylic acid, N-vinyl pyrrolidine, and 2-hydroxy ethyl methacrylate by the technique of molecular imprinting. The polymers are subjected to interaction with creatinine and creatine, a molecule of close resemblance with creatinine. The results show that selectivity is largely governed by the nature of the monomer. The reusability of the polymer is also demonstrated.
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Sreenivasan et al. (1997) studied this question.