Modified oligonucleotides with bulky iodo or lipophilic (hex-1-ynyl) substituents in the 7-position of the 7-deazaadenosine moiety (right) are found to form more stable duplexes than the unmodified oligomers (Tm values, far right). Possible practical applications include the isotopic labeling of DNA, improved delivery of antisense constructs through the cell membrane, and the identification of particular nucleobases by AFM.
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Seela et al. (1998) studied this question.