A familial 10/13 translocation: partial trisomy C in an infant associated with familial 10/13 translocation

An abnormal infant, who died aged 17 d, was found on chromosome examination, to be a partial trisomy C. Clinical and post‐mortem findings are described. Cytogenetic investigation of the family demonstrated the presence of a presumably balanced C/D translocation which had been transmitted through four generations. Fluorescent banding techniques later identified the chromosomes involved in the translocation as being numbers 10 and 13.