[reaction: see text] Ring opening of steroidal spiroketals under exceptionally mild conditions is smoothly achieved via reaction with trifluoroacetyl trifluoromethanesulfonate (TFAT). The new spiroketal ring-opening protocol provides omega-trifluoroacetyl vinyl ethers in good yield and avoids difficulties that attended previously employed vigorous reaction conditions.
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Lee et al. (2003) studied this question.
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