The present study on the developmental course of hypertension in some substrains of SHR with marked differences in the incidence of cerebrovascular lesions clarified that rapidly developed and augmented hypertension was probably related to the higher incidence of cerebrovascular lesions. Accelerated development of severe hypertension in young stage seems to cause greater damage in relatively immature vascular wall and initiate the vicious sequence finally ensuing in cerebrovascular lesions. However, possible involvement of other factors than severe hypertension in the difference of vascular vulnerability in the substrain can not be eliminated and is still under investigation.
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Yamori et al. (1974) studied this question.