Warfarin was converted into O-perfluoroacyl derivatives and separated into enantiomers by capillary GC with chiral stationary phase of polydimethylsiloxane anchored with S(−)-t-leucine-S(−)-1-phenylethylamide. All the derivatives showed almost complete separation. Especially in the case of O-heptafluorobutyryl derivative, baseline separation could be observed.
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Abe et al. (2004) studied this question.
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