What is the clinical evidence from this study?

Study design: Other. Population: Kawasaki disease. Intervention: miR-223 vs. Healthy controls. Primary outcome: miR-223 expression and vascular endothelial cell injury.

February 2, 2017Journal of the American Heart AssociationOpen Access

Bone Marrow–Derived MicroRNA‐223 Works as an Endocrine Genetic Signal in Vascular Endothelial Cells and Participates in Vascular Injury From Kawasaki Disease

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Key result

Blood cell-derived miR-223 was significantly upregulated in patients with Kawasaki disease and entered vascular endothelial cells to induce vascular injury.

Population

Patients with Kawasaki disease and healthy controls; vascular endothelial cells; miR-223 knockout mice and…

Comparison

miR-223 knockdown or knockout vs Healthy controls; wild-type mice

Design

Preclinical

Authors

MCMaoping ChuPediatric Cardiology RWRongzhou WuWenzhou Medical University SQShanshan QinTongji University

Discussion

Member takes

Implication

May represent a therapeutic target in Kawasaki disease; leaves open clinical translation pending human validation.

Structured PICO

Population

Patients with Kawasaki disease and healthy controls; vascular endothelial cells; miR-223 knockout mice and chimeric mice.

Exposure

miR-223 knockdown or knockout

Comparator

Healthy controls; wild-type mice

Outcome

MicroRNA profiles in serum and KD-induced endothelial cell injuriessurrogate

Bone marrow-derived miR-223 acts as an endocrine signal in vascular endothelial cells, contributing to vascular injury in Kawasaki disease and presenting a potential therapeutic target.

Cite This Study

Chu et al. (2017) studied Kawasaki disease. miR-223 vs. Healthy controls was evaluated on miR-223 expression and vascular endothelial cell injury. Blood cell-derived miR-223 was significantly upregulated in patients with Kawasaki disease and entered vascular endothelial cells to induce vascular injury.

synapsesocial.com/papers/6a9edd76fbeca46cb71cdadc https://doi.org/10.1161/jaha.116.004878

Topics

Coronary artery disease

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February 2, 2017Journal of the American Heart AssociationOpen Access

Bone Marrow–Derived MicroRNA‐223 Works as an Endocrine Genetic Signal in Vascular Endothelial Cells and Participates in Vascular Injury From Kawasaki Disease

View Full Paper

Ask AI

Bookmark

Key result

Blood cell-derived miR-223 was significantly upregulated in patients with Kawasaki disease and entered vascular endothelial cells to induce vascular injury.

Population

Patients with Kawasaki disease and healthy controls; vascular endothelial cells; miR-223 knockout mice and…

Comparison

miR-223 knockdown or knockout vs Healthy controls; wild-type mice

Design

Preclinical

Authors

MCMaoping ChuPediatric Cardiology RWRongzhou WuWenzhou Medical University SQShanshan QinTongji University

Discussion

Member takes

Implication

May represent a therapeutic target in Kawasaki disease; leaves open clinical translation pending human validation.

Structured PICO

Population

Patients with Kawasaki disease and healthy controls; vascular endothelial cells; miR-223 knockout mice and chimeric mice.

Exposure

miR-223 knockdown or knockout

Comparator

Healthy controls; wild-type mice

Outcome

MicroRNA profiles in serum and KD-induced endothelial cell injuriessurrogate

Bone marrow-derived miR-223 acts as an endocrine signal in vascular endothelial cells, contributing to vascular injury in Kawasaki disease and presenting a potential therapeutic target.

Cite This Study

synapsesocial.com/papers/6a9edd76fbeca46cb71cdadc https://doi.org/10.1161/jaha.116.004878

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Coronary artery disease

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