Key result
The CCR5 59029 AA genotype was significantly more frequent in patients with chronic Chagas heart disease compared to those with the digestive form (38.0% vs 22.4%, p=0.013), suggesting an association with cardiac susceptibility.
Why the study?
Does the CCR5 59029 A/G polymorphism influence susceptibility to cardiac and digestive clinical forms of chronic Chagas disease?
Case-Control (n=412)
No
Does the CCR5 59029 A/G polymorphism influence susceptibility to cardiac and digestive clinical forms of chronic Chagas disease?
Absolute Event Rate: 38% vs 22.4%
p-value: p=0.013
The CCR5 59029 A/G polymorphism, but not the CCR5Δ32 polymorphism, is associated with susceptibility to different clinical forms of chronic Chagas disease, with the AA genotype more frequent in the cardiac form.
The CCR5 59029 AA genotype was associated with cardiac susceptibility in chronic Chagas disease; hypothesis-generating and requires prospective validation.
The clinical manifestations of chronic Chagas disease include the cardiac form of the disease and the digestive form. Not all the factors that act in the variable clinical course of this disease are known. This study investigated whether the CCR5Δ32 (rs333) and CCR5 59029 A/G (promoter region--rs1799987) polymorphisms of the CCR5 gene are associated with different clinical forms of chronic Chagas disease and with the severity of left ventricular systolic dysfunction in patients with chronic Chagas heart disease (CCHD). The antibodies anti-T. cruzi were identified by ELISA. PCR and PCR-RFLP were used to identify the CCR5Δ32 and CCR5 59029 A/G polymorphisms. The chi-square test was used to compare variables between groups. There was a higher frequency of the AA genotype in patients with CCHD compared with patients with the digestive form of the disease and the control group. The results also showed a high frequency of the AG genotype in patients with the digestive form of the disease compared to the other groups. The results of this study show that the CCR5Δ32 polymorphism does not seem to influence the different clinical manifestations of Chagas disease but there is involvement of the CCR5 59029 A/G polymorphism in susceptibility to the different forms of chronic Chagas disease. Besides, these polymorphisms do not influence left ventricular systolic dysfunction in patients with CCHD.
No takes yet. Share an insight, caveat, or question.
Oliveira et al. (2015) conducted a case-control in Chronic Chagas disease (cardiac and digestive forms) (n=412). CCR5 59029 A/G polymorphism vs. Digestive form of Chagas disease or uninfected controls was evaluated on Frequency of the CCR5 59029 AA genotype (recessive inheritance model) (p=0.013). The CCR5 59029 AA genotype was significantly more frequent in patients with chronic Chagas heart disease compared to those with the digestive form (38.0% vs 22.4%, p=0.013), suggesting an association with cardiac susceptibility.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: