Surgical thrombectomy combined with Antithrombin III concentrate infusion can be a successful treatment for neonatal pulmonary arterial thrombosis due to homozygous Antithrombin III deficiency.
May support thrombectomy plus antithrombin III in rare neonatal thrombosis; leaves open efficacy and generalizability.
We report a newborn male who presented with severe central cyanosis on the third day of life. Partial thrombotic obstruction of the pulmonary trunk secondary to Antithrombin III (homozygous defect of heparin binding site) deficiency was subsequently diagnosed. Surgical thrombectomy, and infusions of Antithrombin III concentrate, led to a successful outcome. We postulate that intrauterine thrombosis occurred to give this unusual presentation.
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Román et al. (2000) studied this question.
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