Blind spectral deconvolution algorithm for Raman spectrum with Poisson noise

A blind deconvolution algorithm with modified Tikhonov regularization is introduced. To improve the spectral resolution, spectral structure information is incorporated into regularization by using the adaptive term to dis-tinguish the spectral structure from other regions. The proposed algorithm can effectively suppress Poisson noise as well as preserve the spectral structure and detailed information. Moreover, it becomes more robust with the change of the regularization parameter. Comparative results on simulated and real degraded Raman spectra are reported. The recovered Raman spectra can easily extract the spectral features and interpret the unknown chemi-cal mixture.