Key result
A new dual impeller centrifugal blood pump with a 45-degree inlet port achieved optimal hydraulic performance and showed no alarming trace of hemolysis in preliminary in vitro testing.
A newly developed dual impeller centrifugal blood pump demonstrated favorable hydraulic performance and low hemolysis in preliminary in vitro testing, suggesting feasibility as a long-term LVAD.
Supports preclinical development of dual-impeller LVADs; leaves open in vivo durability and clinical translation.
A new dual impeller centrifugal blood pump has been developed as a research collaboration between Baylor College of Medicine and Institute Dante Pazzanese of Cardiology for long-term left ventricle assist device (LVAD). A design feature of this new pump is a dual impeller that aims to minimize a stagnant flow pattern around the inlet port. Several different materials were tested in order to adopt a double pivot bearing design originally developed by Prof. Dr. Yukihiko Nosé from Baylor College of Medicine. Hydraulic performance tests were conducted with two different inlet ports' angle configurations 30 degrees and 45 degrees . Pump with inlet port angle of 45 degrees achieved best values of pressure ahead and flow after 1800 rpm. Preliminary hemolysis tests were conducted using human blood. The pump showed good performance results and no alarming trace of hemolysis, proving to be a feasible long-term LVAD.
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Bock et al. (2008) studied Heart failure requiring left ventricular assist device (LVAD). Dual impeller centrifugal blood pump vs. Different inlet port angle configurations (30 degrees vs 45 degrees) was evaluated on Hydraulic performance and hemolysis. A new dual impeller centrifugal blood pump with a 45-degree inlet port achieved optimal hydraulic performance and showed no alarming trace of hemolysis in preliminary in vitro testing.
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