Case with both multiple system atrophy and primary progressive multiple sclerosis with discussion of the difficulty in their differential diagnosis

This is the authors' abstract. We don't add key points for this paper.

Multiple system atrophy (MSA) manifests as a relentlessly progressive disorder incorporating varying combinations of autonomic, cerebellar, and pyramidal dysfunction, and parkinsonism. Primary progressive multiple sclerosis (MS) may also manifest as a progressive disorder incorporating bladder disturbance, and cerebellar and pyramidal dysfunction. Parkinsonism has also been rarely reported in multiple sclerosis, but whether as a consequence of demyelination or as a result of some other coexistent basal ganglia disease remains controversial. We here report an unusual instance of the coincidence in one patient. both clinically and neuropathologically, of MSA and primary progressive MS, and consider the difficulty of differentiating between them.