Nitroethylenes and related compounds as trichomonacides and candidacides

Several of the compounds examined, particularly certain β-nitrostyrenes and di(2- vinyl)benzenes, were highly active in vitro against both Trichomonas vaginalis and Candida albicans, which are commonly found together in vaginitis. The urinary recovery of the compounds after oral administration, however, suggested that the drugs had not gained access to the circulation in amounts sufficient to ensure a worthwhile effect against the organisms and, moreover, they proved irritant to vaginal mucosa.