Key result
Intraluminal administration of poly I:C induced rapid mucosal immune activation and enteropathy in mice, which was exacerbated and prolonged by subsequent oral delivery of the dietary antigen gliadin.
Why the study?
Does intraluminal poly I:C induce enteropathy and is it exacerbated by oral dietary antigen in mice?
Does intraluminal poly I:C induce enteropathy and is it exacerbated by oral dietary antigen in mice?
Intraluminal administration of poly I:C induces acute small intestine damage in mice, which is exacerbated and prolonged by subsequent oral delivery of a dietary antigen like gliadin.
Answers are grounded in this paper and cite their sources.
May model post-viral enteropathy in mice; hypothesis-generating for dietary antigen interactions and leaves open human translation.
Systemic administration of polyinosinic:polycytidylic acid (poly I:C), mimics virally-induced activation of TLR3 signalling causing acute small intestine damage, but whether and how mucosal administration of poly I:C causes enteropathy is less clear. Our aim was to investigate the inflammatory pathways elicited after intraluminal administration of poly I:C and determine acute and delayed consequences of this locally induced immune activation. Intraluminal poly I:C induced rapid mucosal immune activation in C57BL/6 mice involving IFNβ and the CXCL10/CXCR3 axis, that may drive inflammation towards a Th1 profile. Intraluminal poly I:C also caused enteropathy and gut dysfunction in gliadin-sensitive NOD-DQ8 mice, and this was prolonged by concomitant oral administration of gliadin. Our results indicate that small intestine pathology can be induced in mice by intraluminal administration of poly I:C and that this is exacerbated by subsequent oral delivery of a relevant dietary antigen.
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Araya et al. (2014) studied Enteropathy and Gluten Sensitivity. Intraluminal poly I:C and oral gliadin vs. Intraluminal PBS and gluten-free diet was evaluated on Histological enteropathy and gut dysfunction. Intraluminal administration of poly I:C induced rapid mucosal immune activation and enteropathy in mice, which was exacerbated and prolonged by subsequent oral delivery of the dietary antigen gliadin.
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