Key result
Children with celiac disease and dermatitis herpetiformis had significantly higher IgG antibody levels to the adenovirus type 12 E1b peptide compared to matched controls (p < 0.001).
Why the study?
Are adenovirus type 12 (Ad12) E1b protein antibodies associated with an increased risk of celiac disease and dermatitis herpetiformis in children?
Case-Control (n=120)
Are adenovirus type 12 (Ad12) E1b protein antibodies associated with an increased risk of celiac disease and dermatitis herpetiformis in children?
p-value: p=< 0.001
Elevated IgG antibodies to adenovirus type 12 E1b protein suggest a potential viral infectious association with the development of celiac disease and dermatitis herpetiformis.
Supports hypothesis of viral trigger in pediatric celiac disease and dermatitis herpetiformis; leaves open causality and clinical relevance.
The relationship between adenovirus type 12 (Ad12), celiac disease (CD) and dermatitis herpetiformis (DH) was evaluated by enzyme-linked immunosorbent assay (ELISA). Diagnostic phase serum samples from 44 children with CD, 16 children with DH and 60 matched controls were studied for serum antibodies to synthetic peptides derived from an early E1b protein of Ad12 and A gliadin. Both the patient groups had significantly (p < 0.001) higher IgG antibody levels to the Ad12 E1b peptide than the controls. The difference was especially pronounced for girls (p < 0.005). Antipeptide IgG antibodies to Ad12 E1b and A gliadin posed a synergistic increase in the CD and DH risk suggesting that infection with Ad12 is associated with CD and DH.
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Lähdeaho et al. (2009) conducted a case-control in Celiac disease and dermatitis herpetiformis (n=120). Adenovirus type 12 (Ad12) E1b protein antibodies vs. Matched controls was evaluated on IgG antibody levels to the Ad12 E1b peptide (p=< 0.001). Children with celiac disease and dermatitis herpetiformis had significantly higher IgG antibody levels to the adenovirus type 12 E1b peptide compared to matched controls (p < 0.001).
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