Summary HeLa cell cultures were used to propagate 128 rhinovirus strains. Rhinovirus preparations derived from HeLa cells possessed higher infectivity titers than those obtained from human diploid cells. Using identical conditions, attempts to propagate rhinoviruses in HeLa and H.Ep2 cells demonstrated the superiority of the HeLa cell system. Standardization of antisera and identification of viruses were complicated by the presence of cytotoxic factor(s) in many of the antisera. Cytotoxicity could be reduced by treatment with either HeLa cell sediment or human liver powder. The evidence suggests that cytotoxic factor(s) probably are antibodies directed against host cell antigens.
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Conant et al. (1968) studied this question.