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The influence of pH, temperature and light on parthenolide (PRT) content of feverfew was investigated. Feverfew powder and PRT standards mixed in citrate buffers at selected pH (2.4-7.2) were stored for four months. PRT declined in all treatments with greatest loss in solutions with pH below 5, and highest stability in solutions with pH 7.2. PRT in dry samples declined 30 percent after 320 days of storage. Degradation of PRT in feverfew solutions exposed to 40, 60, and 80°C for 24 h increased with increasing temperature. Dry samples exposed to various temperatures revealed stability of PRT at temperatures up to 130°C for short time periods.
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Fonseca et al. (2006) studied this question.
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