Key result
Genetically predicted higher levels of plasma phosphatidylethanolamine (18:0_18:2) were significantly associated with an increased risk of thoracic aortic aneurysm (β = 0.426).
Why the study?
Dyslipidemia has been implicated in increasing the risk of thoracic aortic aneurysm, but the causal relationship between TAA and the plasma lipidome remained to be elucidated.
Does genetically predicted plasma lipidome influence the risk of thoracic aortic aneurysm?
Observational (n=26,820)
Does genetically predicted plasma lipidome influence the risk of thoracic aortic aneurysm?
Mendelian randomization analysis reveals a causal association between increased blood levels of phosphatidylethanolamine (18:0_18:2) and the occurrence of thoracic aortic aneurysm.
May inform TAA risk stratification via lipidomics; leaves open causal validation and therapeutic trials.
Thoracic aortic aneurysm (TAA) refers to the abnormal dilation of the thoracic aorta above the diaphragm, and dyslipidemia has been implicated in increasing the risk of its development. The emergence of lipidomics technology has deepened our understanding of this disease. In this study, we utilized Mendelian randomization analysis (MR) to elucidate the causal relationship between TAA and plasma lipidome. We found a strong correlation between increased levels of phosphatidylethanolamine (18:0_18:2) in the blood and occurrence of TAA. Our research also revealed that TAA may lead to a decrease in levels of phosphatidylcholine (16:0_18:3), phosphatidylcholine (18:2_20:4), and phosphatidylcholine (O − 17:0_17:1) in the plasma. Through genetic techniques, our study has shed light on the close relationship between TAA and plasma lipidome, providing direction for future clinical research.
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GuangTao et al. (2025) conducted an observational in Thoracic aortic aneurysm (n=26,820). Genetically predicted plasma phosphatidylethanolamine (18:0_18:2) levels vs. Lower genetically predicted levels was evaluated on Risk of thoracic aortic aneurysm (β = 0.426, 95% CI 1.079-2.170, p=0.017). Genetically predicted higher levels of plasma phosphatidylethanolamine (18:0_18:2) were significantly associated with an increased risk of thoracic aortic aneurysm (β = 0.426).
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