Key result
Elevated CCL18 and CCL5 levels at day 180 were associated with early and late left ventricular ejection fraction <35% in patients with acute anterior myocardial infarction (p=0.05 and p=0.042).
Why the study?
Do CCL5 and CCL18 levels correlate with early and late ejection fractions in patients with acute anterior myocardial infarction?
Cohort (n=50)
Do CCL5 and CCL18 levels correlate with early and late ejection fractions in patients with acute anterior myocardial infarction?
p-value: p=0.05 and 0.042
CCL18 levels correlate with cardiac function and may serve as a prognostic indicator of poor LVEF in patients with acute anterior myocardial infarction.
Hypothesis-generating for CCL18/CCL5 as post-MI LVEF biomarkers; prospective validation required before clinical adoption.
BACKGROUND: Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries. OBJECTIVE: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia. METHODS: In this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction (AAMI) for developing cardiovascular accidents in a 6-month period. CCL5 and CCL18 levels were measured on admission, at day 5 and at day 180 post-hospitalization. RESULTS: CCL18 and CCL5 levels at day 180 were higher in patients with late (day 180) and early (day 5) LVEF less than 35% compared to those with higher LVEF (p=0.05 and p=0.042, respectively). There was a negative correlation between early and late LVEF and regional wall motion abnormalities (p=0.001 and p=0.002, respectively). There was also a trend of negative correlation between CCL18 levels at day 5 and LVEF levels at day 180 post-hospitalization (p=0.06). CONCLUSION: CCL18 has a correlation with cardiac function in patients with AAMI and it might be considered as an indicator of poor LVEF in patients with AAMI.
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Khanian et al. (2016) conducted a cohort in Acute anterior myocardial infarction (n=50). CCL5 and CCL18 levels was evaluated on Left ventricular ejection fraction (LVEF) <35% (p=0.05 and 0.042). Elevated CCL18 and CCL5 levels at day 180 were associated with early and late left ventricular ejection fraction <35% in patients with acute anterior myocardial infarction (p=0.05 and p=0.042).
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