Key result
Doxorubicin therapy caused a time-dependent decrease in cardiac levels of GPOX (10% inhibition), GR (12% inhibition), and GSH (15% decrease) at 7 days post second treatment.
Population
Male balb/c mice
Design
Preclinical
Follow-up
7 days following the second treatment
Authors
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May heighten cardiac oxidative vulnerability after doxorubicin in animals; leaves open relevance to human cardiotoxicity prevention.
Therapeutic dosing of doxorubicin decreases cardiac antioxidant defenses (GPOX, GR, and GSH), which may render the heart susceptible to further oxidative damage.
Gustafson et al. (1993) studied Doxorubicin-induced cardiotoxicity. Doxorubicin was evaluated on Activities of antioxidant enzymes (SOD, CAT, GPOX, GR) and GSH levels in heart and kidney. Doxorubicin therapy caused a time-dependent decrease in cardiac levels of GPOX (10% inhibition), GR (12% inhibition), and GSH (15% decrease) at 7 days post second treatment.
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