Why the study?
Does a transradial approach reduce adverse clinical events and bleeding compared to a transfemoral approach in patients with STEMI undergoing primary PCI?
Population
3,340 patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary…
Comparison
Transradial (TR) approach (n=200) vs Transfemoral (TF) approach (n=3,134)
Design
Cohort
Follow-up
1 year
Key result
Transradial access for primary PCI in STEMI was associated with significantly lower 30-day MACE compared to transfemoral access (2.0% vs. 5.6%; OR 0.35; 95% CI 0.13-0.95; p=0.02).
Authors
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May favor transradial access in STEMI primary PCI; leaves open need for randomized confirmation before practice change.
Observational (n=3,340)
Does a transradial approach reduce adverse clinical events and bleeding compared to a transfemoral approach in patients with STEMI undergoing primary PCI?
Odds Ratio: 0.35 (95% CI 0.13–0.95)
Absolute Event Rate: 2% vs 5.6%
p-value: p=0.02
In patients with STEMI undergoing primary PCI, a transradial approach is associated with reduced major bleeding and improved event-free survival compared to a transfemoral approach.
Généreux et al. (2011) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=3,340). Transradial (TR) approach vs. Transfemoral (TF) approach was evaluated on 30-day major adverse cardiovascular events (MACE) (OR 0.35, 95% CI 0.13-0.95, p=0.02). Transradial access for primary PCI in STEMI was associated with significantly lower 30-day MACE compared to transfemoral access (2.0% vs. 5.6%; OR 0.35; 95% CI 0.13-0.95; p=0.02).