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Prematurity is the primary etiologic factor for retrolental fibroplasia, with the incidence of the disease increasing alongside greater degrees of premature birth.
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This historical note highlights prematurity as the primary etiologic factor for retrolental fibroplasia, a vascular disease causing infantile blindness.
RETROLENTAL fibroplasia is now the commonest late complication of extremely premature birth. Until 15 years ago, blindness from this cause was so rare that the disease was not recognized. Terry,1in 1942, wrote the first descriptions of retrolental fibroplasia as an entity and later named the disease.2Since that time, the literature about this form of infantile blindness has grown rapidly, and many investigators have sought the nature of the pathology, pathogenesis, clinical manifestations, etiologic factors, and therapeusis of the disease. HISTORY We are indebted to Terry not only for first calling our attention to retrolental fibroplasia, but also for pointing out the etiologic factor3that has borne the test of time—prematurity. It is now agreed that the greater the degree of prematurity, the greater the incidence of retrolental fibroplasia.4Owens and Owens7described the clinical pathogenesis of the disease: a vascular phenomenon, characterized by
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W. R. Hepner (1954) conducted a review in Retrolental fibroplasia. Prematurity was evaluated. Prematurity is the primary etiologic factor for retrolental fibroplasia, with the incidence of the disease increasing alongside greater degrees of premature birth.
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