Surfactant‐Free Synthesis of SnO2@PMMA and TiO2@PMMA Core–Shell Nanobeads Designed for Peptide/Protein Enrichment and MALDI‐TOF MS Analysis

Extremely low concentrations of peptides and proteins can be enriched from complex solutions by SnO2@PMMA and TiO2@PMMA core–shell nanobeads with controlled size and composition (see picture for schematic synthesis), and their MALDI-TOF MS signal intensities and signal-to-noise ratios are also significantly improved. These effects are ascribed to the physical properties and structure of the nanobeads. PMMA=poly(methyl methacrylate).