Highly efficient continuous-flow asymmetric catalysis was achieved by combination of supported ionic liquid phase (SILP) catalysts with supercritical CO2 (scCO2) as the mobile phase, as demonstrated for enantioselective hydrogenation in the presence of a molecular rhodium–QUINAPHOS complex. The integrated reaction and separation process yielded chemically and enantiomerically pure products without the need for organic solvents.
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Hintermair et al. (2010) studied this question.