Do Resistin and Resistin-Like Molecules Also Link Obesity to Inflammatory Diseases?

Letters21 August 2001Do Resistin and Resistin-Like Molecules Also Link Obesity to Inflammatory Diseases?Javier Gómez-Ambrosi, PhD and Gema Frühbeck, MD, PhDJavier Gómez-Ambrosi, PhDUniversity of Navarra, 31008 Pamplona, Spain (Gómez-Ambrosi)Clínica Universitaria de Navarra, 31008 Pamplona, Spain (Frühbeck) and Gema Frühbeck, MD, PhDUniversity of Navarra, 31008 Pamplona, Spain (Gómez-Ambrosi)Clínica Universitaria de Navarra, 31008 Pamplona, Spain (Frühbeck)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-4-200108210-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Recently, Steppan and colleagues (1) described the discovery of a novel hormone, which they called resistin (for resistance to insulin). Resistin is specifically expressed and secreted by adipocytes, apparently in proportion to fat-pad size, and it impairs glucose tolerance and insulin action; thus, it links obesity to diabetes. Resistin seems to be part of an emerging new family of secreted proteins that have a tissue-specific pattern of expression and probably have common signaling characteristics. To date, two other members of the family (resistin-like molecule [RELM-α and RELM-β] have been cloned (2). The former is expressed in white ...References1. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al . The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12. [PMID: 11201732] CrossrefMedlineGoogle Scholar2. Steppan CM, Brown EJ, Wright CM, Bhat S, Banerjee RR, Dai CY, et al . A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci U S A. 2001;98:502-6. [PMID: 11209052] CrossrefMedlineGoogle Scholar3. Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, Henzel W, et al . FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000;19:4046-55. [PMID: 10921885] CrossrefMedlineGoogle Scholar4. Vgontzas AN, Bixler EO, Papanicolaou DA, Chrousos GP. Chronic systemic inflammation in overweight and obese adults. JAMA. 2000;283:2235. [PMID: 10807374] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Navarra, 31008 Pamplona, Spain (Gómez-Ambrosi)Clínica Universitaria de Navarra, 31008 Pamplona, Spain (Frühbeck) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByActivation of Noncanonical Wnt Signaling Through WNT5A in Visceral Adipose Tissue of Obese Subjects Is Related to InflammationRegulation of adipocyte lipolysisMechanisms Linking Excess Adiposity and Carcinogenesis PromotionObesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose TissuePeripheral signalling involved in energy homeostasis controlInflammation: The Link Between Obesity and Cardiovascular RiskThe significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer (NSCLC)Effect of moderate alcohol consumption on adipokines and insulin sensitivity in lean and overweight men: a diet intervention studyCentral Resistin Regulates Hypothalamic and Peripheral Lipid Metabolism in a Nutritional-Dependent FashionAdipocitocinas: uma nova visão do tecido adiposoEndothelial dysfunction in vivo is related to monocyte resistin mRNA expressionHypothalamic resistin induces hepatic insulin resistanceA novel role for Oct-2 in the lipopolysaccharide-mediated induction of resistin gene expression in RAW264.7 cellsAssociations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitusWithin-subject variation of plasma resistin levels over a 1-year periodThe Sir David Cuthbertson Medal Lecture Hunting for new pieces to the complex puzzle of obesityAdipose Tissue Has Anti-Inflammatory Properties: Focus on IL-1 Receptor Antagonist (IL-1Ra)Lung function in type 2 diabetes: the Normative Aging StudySerum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi populationAssociation of Plasma Resistin Levels with Coronary Heart Disease in WomenEffects of free fatty acids on plasma resistin and insulin resistance in awake ratsAssociations Between Serum Resistin Levels and Insulin Resistance, Inflammation, and Coronary Artery DiseaseSerum amyloid A: production by human white adipocyte and regulation by obesity and nutritionRole of adipocytokines in metabolism and diseaseCirculating Adiponectin and Resistin Levels in Relation to Metabolic Factors, Inflammatory Markers, and Vascular Reactivity in Diabetic Patients and Subjects at Risk for DiabetesRole of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic ApproachResistin - concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory diseaseReductions in plasma cholesterol levels after fenofibrate treatment are negatively correlated with resistin expression in human adipose tissueResistin overexpression is induced by a β3 adrenergic agonist in diet-related overweightnessVasoactive Factors and Inflammatory Mediators Produced in Adipose Tissue 21 August 2001Volume 135, Issue 4Page: 306-307KeywordsHormonesInflammationInsulin resistanceInsulin secretionLungsNecrosisObesityProteinsResistinTongue ePublished: 21 August 2001 Issue Published: 21 August 2001 CopyrightCopyright © 2001 by American College of Physicians. 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