Catecholamine Depletion and Uptake in Adrenergic Nerve Vesicles and in Rabbit Organs after Decaborane

Euler. U. S. v. and F. Lishajko. Catecholamine depletion and uptake in adrenergic neme vesicles and in rabbit organs after decaborane. Acta physiol. scand. 1965. 65. 324–330. — Decaborane (B10H14) increases the release rate of noradrenaline (NA) from isolated nerve vesicles in concentrations of 10‐5 M and stronger. The NA retention in nerve vesicles incubated in the presence of NA and of ATP is decreased by decaborane 10‐4 M which also inhibits the ATP‐dependent NA uptake in partially depleted vesicles. In a dose of 4 mg/kg i.p. decaborane gradually decreases the catecholamine stores in various organs of the rabbit. Between 23–48 hours after the decaborane injection the NA content in the heart is about 10–20 per cent of the normal value. Injection of NA. 0.3–0.4 mg/kg i. m., increases the NA content in the heart to near normal in 1–2 hrs, whereafter it falls to the previous low value in some 20 hrs. The NA taken up by the rabbit heart after depletion with decaborane is distributed between the high speed sediment and the supernatant in the same proportions as found in the normal heart suggesting a dynamic equilibrium between the vesicles and the non‐vesicular pool.