Key result
Seroepidemiological surveys in Singapore revealed neutralising antibody prevalences of 19.1% for CA24v and 66.9% for EV70, with a significant correlation between the two viruses (P=7.75 x 10^-3).
Cross-Sectional
p-value: p=7.75 x 10(-3)
Seroepidemiological data suggest that epidemics of acute haemorrhagic conjunctivitis in Singapore may be triggered when herd immunity falls below a critical level.
Supports AHC outbreak forecasting via serosurveillance in Singapore; leaves open causal herd-immunity thresholds and dual-virus dynamics.
Epidemics of acute haemorrhagic conjunctivitis caused by a variant of coxsackievirus A24 (CA24v) and enterovirus 70 (EV70) have occurred periodically in Singapore. A seroepidemiological survey conducted before the CA24v epidemic in 1985 and in the midst of the EV70 epidemic in 1983 showed a neutralising antibody prevalence (greater than or equal to 1:4) of 19.1% and 66.9% to CA24v and EV70, respectively. The seropositivity rate to both viruses was highest in children 10-14 years of age, but no sex or ethnic difference was noted. It appears from the data that an epidemic could be triggered when the herd immunity of the population falls below a critical level. There was a significant correlation in seroprevalence between CA24v and EV70 (P = 7.75 x 10(-3).
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Goh et al. (1990) conducted a cross-sectional in Acute haemorrhagic conjunctivitis. Coxsackievirus A24 variant (CA24v) and enterovirus 70 (EV70) was evaluated on Neutralising antibody prevalence (≥ 1:4) to CA24v and EV70 (p=7.75 x 10(-3)). Seroepidemiological surveys in Singapore revealed neutralising antibody prevalences of 19.1% for CA24v and 66.9% for EV70, with a significant correlation between the two viruses (P=7.75 x 10^-3).
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