Key result
Mean pulmonary capillary wedge pressure significantly correlated with the deceleration of left ventricular early diastolic filling flow (r=0.606, p<0.01), indicating that left atrial pressure may mask the relationship between filling parameters and left ventricular relaxation.
Observational (n=19)
Single-blind
No
The level of left atrial pressure can mask the relationship between Doppler-derived indices of left ventricular early diastolic filling and the time constant of left ventricular relaxation in chronic stable patients.
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LA pressure may mask Doppler indices of LV relaxation in stable patients; leaves open need for pressure-adjusted validation in prospective studies.
We analyzed the relationships among parameters of left ventricular (LV) early diastolic filling flow (EDF) obtained with pulsed Doppler echocardiography, mean pulmonary wedge pressure (PCWP) and the time constant of LV pressure fall calculated by either Weiss' (Tw) or Thompson's (Tb) method. PCWP correlated with the peak velocity (R) (r = 0.537, p less than 0.05), acceleration (Ac) (r = 0.545, p less than 0.05) and deceleration (Dc) (r = 0.606, p less than 0.01) of LVEDF. In contrast, Tb correlated only with the time to the peak of LVEDF (TPF) (r = 0.487, p less than 0.05), and Tw did not correlate with the Doppler-derived indices significantly. After correcting for the effect of PCWP, significant partial correlations between R and Tw (r = -0.535, p less than 0.05), and between Ac and both Tw (r = -0.606, p less than 0.01) and Tb (r = -0.569, p less than 0.05) were found. Dc did not correlate with Tw or Tb. These results suggest that the level of left atrial pressure may mask the relationship between parameters of LVEDF and LV relaxation, and that the relations among these variables vary with individual indices of LVEDF.
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Takahashi et al. (1990) conducted an observational in Cardiac diseases (n=19). Mean pulmonary capillary wedge pressure (PCWP) was evaluated on Correlation between PCWP and deceleration (Dc) of left ventricular early diastolic filling flow (r=0.606, p=<0.01). Mean pulmonary capillary wedge pressure significantly correlated with the deceleration of left ventricular early diastolic filling flow (r=0.606, p<0.01), indicating that left atrial pressure may mask the relationship between filling parameters and left ventricular relaxation.
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