Key result
Oxytocin-Gly-Lys-Arg (OT-GKR) induced contracting cell colonies and ventricular cardiomyocyte markers in embryonic P19 cells more potently than oxytocin (9 vs 5 colonies at day 8, p<0.05).
Why the study?
Does Oxytocin-Gly-Lys-Arg (OT-GKR) promote cardiomyocyte differentiation in embryonic P19 cells?
Does Oxytocin-Gly-Lys-Arg (OT-GKR) promote cardiomyocyte differentiation in embryonic P19 cells?
OT-GKR, a processing intermediate of oxytocin, potently stimulates cardiomyocyte differentiation and may contribute to heart growth during fetal life.
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Danalache et al. (2010) studied Cardiomyogenesis. Oxytocin-Gly-Lys-Arg (OT-GKR) vs. Oxytocin (OT) and non-induced controls was evaluated on Number of contracting cell colonies at day 8 (p=<0.05). Oxytocin-Gly-Lys-Arg (OT-GKR) induced contracting cell colonies and ventricular cardiomyocyte markers in embryonic P19 cells more potently than oxytocin (9 vs 5 colonies at day 8, p<0.05).
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