Key result
Exercise tolerance and heart rate recovery were significantly correlated with average systolic blood pressure (r = 0.46 for Load AT) and the frequency of intradialytic hypotension (r = -0.44) in maintenance hemodialysis patients.
Why the study?
This study investigated the association between the blood pressure response during hemodialysis and exercise tolerance or heart rate recovery measured with cardiopulmonary exercise testing.
Does exercise tolerance and heart rate recovery correlate with blood pressure instability during hemodialysis in maintenance hemodialysis patients?
Cross-Sectional (n=23)
No
Does exercise tolerance and heart rate recovery correlate with blood pressure instability during hemodialysis in maintenance hemodialysis patients?
Exercise intolerance and impaired heart rate recovery are significantly associated with blood pressure instability during hemodialysis, suggesting a role for autonomic dysfunction in intradialytic hemodynamics.
Answers are grounded in this paper and cite their sources.
Intradialytic BP instability was associated with reduced exercise tolerance and impaired HR recovery; leaves open whether autonomic dysfunction drives hemodynamics in MHD patients.
Background This study investigated the association between the blood pressure response during hemodialysis (HD) and exercise tolerance or heart rate recovery (HRR) measured with cardiopulmonary exercise testing (CPX). Methods The study enrolled 23 patients who had been undergoing 4-h regular maintenance HD. The maximum workload (Loadpeak), peak oxygen uptake (VO2peak), workload and oxygen uptake at the anaerobic threshold (LoadAT and VO2AT, respectively), and HRR were measured with CPX. The average systolic blood pressure during HD (SBPav) was measured, and the number of times the SBP was less than 100 mmHg was determined in the 2-week period after CPX. Results The SBPav showed a significant correlation with LoadAT (r = 0.46) and Loadpeak (r = 0.43, p < 0.05). The number of times the SBP was less than 100 mmHg showed a significant correlation with the HRR (r = − 0.44, p < 0.05). Conclusion Exercise intolerance and HRR in HD patients may be associated with blood pressure instability during HD.
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Yabe et al. (2020) conducted a cross-sectional in Chronic kidney disease on maintenance hemodialysis (n=23). Exercise tolerance and heart rate recovery was evaluated on Correlation between average systolic blood pressure during hemodialysis and exercise tolerance (Load AT) (r = 0.46, p=<0.05). Exercise tolerance and heart rate recovery were significantly correlated with average systolic blood pressure (r = 0.46 for Load AT) and the frequency of intradialytic hypotension (r = -0.44) in maintenance hemodialysis patients.
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