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March 8, 2012Journal of Clinical MicrobiologyOpen Access

Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in São Paulo, Brazil

Nathalia Mantovani R Gonçalves Azevedo J. T. Rabelato Sabri Saeed Sanabani Ricardo Sobhie Diaz Shirley Vasconcelos Komninakis

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Abstract

We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.

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Mantovani et al. (2012) studied this question.

synapsesocial.com/papers/6a9f65acdc942fc4a59655ef https://doi.org/10.1128/jcm.00539-12

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