Background : Office hysteroscopy with endometrial biopsy is usually the investigation for abnormal uterine bleeding and other uterine. Aims: To evaluate the effect of oral drotaverine with acid on pain perception during hysteroscopy and endometrial and to compare it with that of paracervical block using 1% and with that of intravenous sedation using diazepam with. Settings and Design : Outpatient gynecological department open randomized trial. Materials and Methods : One hundred twenty undergoing hysteroscopy and endometrial biopsy were randomized 3 groups. Group I received tablet containing drotaverine (80 mg) + mefenamic acid (250 mg), group II received paracervically and group III received intravenous diazepam. intensity of pain during the procedure, 30 and 60 minutes later on analog scale (VAS) was assessed. Statistical Analysis : analysis was performed using Kruskal-Wallis test, with the correction, the t test, and the χ2 test. Results: were similar in age, parity, vaginal birth or relevant medical. A statistically significant difference in pain scores was among the 3 groups during the procedure (group I, 4.13±1.28; group II, 5.93± 1.26; group III, 5.58± 1.51), (P<0.001); as well as 30 minutes later (group I, 1.78± 0.89; group, 2.53± 0.81; group III, 2.23± 0.94), (P< 0.001) and 60 later (group I, 1.2± 0.46; group II, 1.98± 0.83; III, 1.68± 0.75), (P< 0.001). VAS at different time among the groups was also statistically significant. No effects were observed. Conclusions : Oral drotaverine with acid is effective in women undergoing hysteroscopy and biopsy.
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Sharma et al. (2009) studied this question.
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