Value of Troponin T Versus I in the Diagnosis of Immune Checkpoint Inhibitor-Related Myocarditis and Myositis: Rechallenge?

Figures

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  Figure 1. Cardiac magnetic resonance. Initial cardiac magnetic resonance imaging showing elevated T2‐mapping times and oedema in the left ventricular basal segments (left: 57 ms, normal values: 48 ± 3 ms). No scars, fibrosis or late gadolinium enhancement of the left and right ventricles. Normal T1‐mapping times (988 ms, normal values: 989 ± 28 ms).

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  Figure 2. Immune checkpoint inhibitor‐related myocarditis and myositis time course. Graphical representation of the clinical course of hs‐TnT (orange points and line), hs‐TnI (grey), NT‐proBNP (yellow), and CK (blue) over time in relation to ICI administration (arrows) and therapy for myocarditis. CK, creatine kinase; hs‐TnT, high‐sensitivity troponin T; hs‐TnI, high‐sensitivity troponin I; ICIs, immune checkpoint inhibitors; NT‐proBNP, N‐terminal pro‐hormone B natriuretic peptide.

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  Figure 3. FDG‐positron emission tomography. (A) First FDG‐positron emission tomography showing melanoma metastases in the lungs, regional lymph nodes, peritoneum, and adrenal glands. (B) Follow‐up FDG‐positron emission tomography showing progression of melanoma metastases in the lungs, regional lymph nodes and in the soft tissue and skeletal muscles (left gluteus minimus and right acromion).