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The Michael addition of adenine (6a), 6-chloropurine (6b) and 2,6-dichloropurine (6c) to methyl α-chloroacrylate gives high yields of the corresponding adducts (7a-7c). Hydrolysis and amination of 7a gave the adenyl analogue of Willardiine (2).
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Nollet et al. (1969) studied this question.
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