Key result
Thrombosis after central venous catheter insertion mainly occurred at sections where blood flow lost spiral rotation, with incidence rates varying significantly across different vein segments (P < 0.05).
Why the study?
What hemodynamic parameters predispose hemodialysis patients to thrombosis after tunneled cuffed central venous catheter placement?
Observational (n=120)
No
What hemodynamic parameters predispose hemodialysis patients to thrombosis after tunneled cuffed central venous catheter placement?
The destruction of spiral flow rotation in the central vein after CVC insertion appears to be a key precursor to thrombus formation, suggesting that preserving or introducing spiral flow could be protective.
Spiral flow loss may flag post-CVC thrombosis risk in hemodialysis; hypothesis-generating for flow-preserving catheter designs.
The tunneled central venous catheter (CVC) plays an important role for hemodialysis patients, but CVC-related thrombosis in the central veins remain problematic. This study is the first try to numerically find out what hemodynamic parameters are predisposed to the initiation and formation of thrombus after CVC insertion. And the potential relationship between hemodynamic parameters and the incidence rates of thrombosis occurrence was explored. The results revealed that the CVC insertion led to a significant increase of hydraulic resistance, wide-ranging abnormally high wall shear stress (WSS), and a great loss of flow rotation in the vein. Moreover, the clinical data showed that thrombosis mainly occurred at sections where most blood flow lost spiral rotation after the CVC insertion, but no corresponding match was observed between the occurrence of thrombosis and the flow velocity or WSS. We speculate that the destruction of the flow rotation in the central vein is a precursor to the thrombus formation around CVC, and an introduction of spiral flow with the CVC insertion may possibly help to protect the central vein from thrombosis. Further animal and clinical experiments should be carried out to test and verify this speculation.
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Peng et al. (2017) conducted an observational in End stage renal disease requiring hemodialysis with tunneled central venous catheter (n=120). Tunneled cuffed central venous catheter placement vs. Central veins without central venous catheter (simulated) was evaluated on Incidence rate of thrombosis at different cross sections of the central veins (p=<0.05). Thrombosis after central venous catheter insertion mainly occurred at sections where blood flow lost spiral rotation, with incidence rates varying significantly across different vein segments (P < 0.05).
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