"PaO2 Levels and Retrolental Fibroplasia: A Report of the Cooperative Study" (p. 655) presents a great deal of data on a very important subject. There is considerable evidence that hyperoxemia and retrolental fibroplasia (RLF) are related, and the story of how this association was identified along with the history of the use of oxygen in sick newborn infants have recently been reviewed.1 The study reported here was designed to answer two questions. What level of PaO2 and what length of exposure to high PaO2 would cause RLF? It was hoped that a "safe" level of PaO2 in immature infants could be established.
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Tooley et al. (1977) studied this question.