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June 25, 2009The Journal of Organic Chemistry

On the Emerging Role of Chemistry in the Fashioning of Biologics: Synthesis of a Bidomainal Fucosyl GM1-Based Vaccine for the Treatment of Small Cell Lung Cancer

Pavel Nagorny Woo Han Kim Qian Wan Dongjoo Lee Samuel J. Danishefsky

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Abstract

The synthesis of the novel small cell lung cancer (SCLC) fucosyl GM1-based vaccine construct, featuring insertion of the HLA-DR binding 15 amino acid sequence derived from Plasmodium falciparum, is described. The resultant glycopeptide has been synthesized in an efficient manner. Finally, successful conjugation of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein completed the preparation of the vaccine.

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Nagorny et al. (2009) studied this question.

synapsesocial.com/papers/6a9f71c65a8b0dbb8a04f0e6 https://doi.org/10.1021/jo900918m

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