A novel metal-free C( sp 3 )–H amination of 2-oxindoles with alkylamines to afford C–N coupling products under mild conditions has been exploited. A series of 3-substituted 2-oxindoles and primary/secondary amines substrates were found to be well tolerated, affording the corresponding 3-substituted 3-aminooxindoles in 43%–92% yields. This method uses the economical and environmentally friendly “I 2 –TBHP” system, and the mechanistic studies revealed that the procedure undergoes through a radical pathway.
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Wei et al. (2018) studied this question.
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