Key result
Flow-mediated dilatation was not significantly different between diabetic patients with impaired versus normal early left ventricular relaxation, though it was negatively associated with E/E' in those with impaired relaxation.
Cross-Sectional (n=82)
No
Absolute Event Rate: 5% vs 5.1%
p-value: p=0.96
In uncomplicated Type 2 diabetic patients, flow-mediated dilatation is negatively associated with E/E' in those with impaired early left ventricular relaxation.
Objectives: To evaluate the association of diastolic function of the left ventricle with flowme-diated dilatation (FMD) in uncomplicated Type 2 diabetes mellitus patients. Methods: Eighty-two uncomplicated Type 2 diabetic patients were examined by pulse and tissue Doppler echocardiography and FMD of brachial artery. The patients were divided into 2 groups according to the size of the left ventricular relaxation parameter—E’. Results: The average age of the patients was 61 ± 6 years. FMD was 5.0 ± 1.8% in 41 patients with E’ from 3 to 7.4 cm/s (mean 6 cm/s) comparing to 5.1 ± 1.9% (p = 0.96) in 41 patients with E’ from 7.5 to 10.9 cm/s (mean 8.9 cm/s). E/E’ was 11.2 ± 2.3 in the group with lower E’ and 9.1 ± 1.6 in the group with higher E’ (p 0.001). Linear negative correlation was found between E/E’ and FMD for the patients with E’ from 3 to 7.4 cm/s (R2 = 0.131; p = 0.025) but not for the group of patients with the higher E’. The significant association between FMD and E/E’ was confirmed by multivariate analysis ((Rc)2 = 0.233; p 0.05). Conclusion: FMD has no impact on the left ventricular relaxation. However FMD is negatively associated with E/E’ in Type 2 diabetic patients who have low E’ as a sign of an impaired early relaxation.
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Charvát et al. (2013) conducted a cross-sectional in Uncomplicated Type 2 diabetes mellitus (n=82). Impaired early left ventricular relaxation (E' 3 to 7.4 cm/s) vs. Normal early left ventricular relaxation (E' 7.5 to 10.9 cm/s) was evaluated on Maximum flow-mediated dilatation (FMD) (p=0.96). Flow-mediated dilatation was not significantly different between diabetic patients with impaired versus normal early left ventricular relaxation, though it was negatively associated with E/E' in those with impaired relaxation.
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